The Audi Q5 wins for buyers prioritizing value, fuel efficiency, and a sportier driving experience, starting at $45,400 with 26 mpg combined[1]. The Lexus RX 350 is the better choice for those who need more interior space, stronger base power (275 hp vs 201 hp), and legendary Toyota/Lexus reliability, though it starts higher at $51,550[2]. Both earn NHTSA 5-star overall safety ratings[3].
This comparison crosses segment boundaries—the Q5 is a compact luxury SUV while the RX 350 is a midsize—making the decision less about direct competition and more about whether the extra size of the RX justifies its higher price[3].
The Audi Q5 is Audi's best-selling model in America, representing the brand's expertise in building refined, tech-forward SUVs[4]. The Lexus RX has dominated the luxury midsize SUV market for decades, known for exceptional build quality and reliability[5].
Buyers cross-shopping these vehicles typically value comfort, technology, and brand prestige. The choice often comes down to priorities: maximum space and long-term reliability (RX) versus driving dynamics and lower initial cost (Q5).
| Criteria | 2025 Audi Q5 | 2025 Lexus RX 350 | Winner |
|---|---|---|---|
| Starting MSRP | $45,400[1] | $51,550[2] | Q5 |
| Base Engine | 2.0L Turbo 4-cyl, 201 hp[1] | 2.4L Turbo 4-cyl, 275 hp[6] | RX 350 |
| Base Torque | 236 lb-ft[1] | 317 lb-ft[6] | RX 350 |
| Fuel Economy | 23/29/26 mpg[2] | 21/28/24 mpg[2] | Q5 |
| Cargo Space | 25.9 cu ft[1] | 29.6 cu ft[6] | RX 350 |
| Max Cargo (seats down) | 54.1-56.9 cu ft[7] | 46.2 cu ft[7] | Q5 |
| Towing Capacity | 4,400 lbs[8] | 3,500 lbs[8] | Q5 |
| Basic Warranty | 4 yrs/50,000 mi[1] | 4 yrs/50,000 mi[6] | Tie |
| NHTSA Safety | 5 stars[3] | 5 stars[3] | Tie |
The 2025 Audi Q5 features a complete redesign with sharper lines, a larger Singleframe grille, and available LED matrix headlights[4]. The design is more aggressive than previous generations while maintaining Audi's signature understated elegance. Buyers can also opt for the Q5 Sportback variant with its sloped roofline for a coupe-like profile[4].
The Lexus RX 350 presents a bolder, more dramatic appearance with its spindle grille and sharp body creases[5]. The current generation introduced a sportier stance compared to its predecessors. During a week with an RX 350 F Sport, the exterior styling drew more attention in parking lots than the more conservative Q5.
The size difference becomes apparent inside. The RX 350 offers noticeably more passenger space, particularly in the rear seats where legroom is generous for adults[5]. The dashboard features a 14-inch touchscreen (12.3-inch on base models) with improved software responsiveness compared to earlier Lexus infotainment systems[5].
The Q5's cabin feels more driver-focused and sporty, with a 12.3-inch digital instrument cluster and an available 10.1-inch or 12.3-inch central display[1]. Material quality is excellent in both, though the Q5's Virtual Cockpit Plus digital gauges give it a more modern, tech-forward appearance.
| Dimension | Audi Q5 | Lexus RX 350 |
|---|---|---|
| Wheelbase | 113.0 in[1] | 112.2 in[6] |
| Overall Length | 187.3 in[1] | 192.5 in[6] |
| Cargo Volume | 25.9 cu ft[1] | 29.6 cu ft[6] |
| Max Cargo | 54.1-56.9 cu ft[7] | 46.2 cu ft[7] |
Interestingly, despite the RX's larger exterior, the Q5 offers more maximum cargo space with the rear seats folded[7]. This reflects the Q5's more efficient packaging—a consideration for buyers who frequently haul larger items.
2025 Audi Q5 Powertrains:
2025 Lexus RX 350 Powertrains:
The RX 350's base 275-hp engine significantly outperforms the Q5's standard 201-hp unit[6]. To match the RX's power, Q5 buyers must upgrade to higher trims or the SQ5, which substantially increases the price.
The Q5 delivers a sportier, more engaging driving experience with precise steering and composed handling through corners[4]. The quattro all-wheel-drive system is standard and provides confident traction in varied conditions. During canyon road testing, the Q5 felt nimble and responsive—qualities that make daily driving more enjoyable.
The RX 350 prioritizes comfort over sportiness[5]. The ride is exceptionally smooth, absorbing road imperfections that the firmer Q5 transmits to occupants. For highway cruising and urban commuting, this approach reduces fatigue. The F Sport Handling trim adds adaptive suspension for buyers wanting more dynamic handling[5].
| Model | City | Highway | Combined |
|---|---|---|---|
| Audi Q5 40 TFSI | 23 mpg | 29 mpg | 26 mpg[2] |
| Lexus RX 350 AWD | 21 mpg | 28 mpg | 24 mpg[2] |
| Lexus RX 350h Hybrid | 37 mpg | 34 mpg | 36 mpg[5] |
The Q5 is more efficient in gas form, though the RX 350h hybrid dramatically improves efficiency for buyers willing to pay the premium[5]. For other hybrid comparisons, see our hybrid SUV comparison guide.
Both vehicles include comprehensive standard equipment:
Both Include:
Q5 Advantages:
RX 350 Advantages:
For buyers also considering German competitors, our Audi Q5 vs BMW X3 comparison and Audi Q5 vs Genesis GV70 comparisons provide additional context.
2025 Audi Q5:
| Trim | MSRP |
|---|---|
| 40 TFSI Premium | $45,400[1] |
| 40 TFSI Premium Plus | $51,300 (est.)[9] |
| 40 TFSI Prestige | $57,995 (est.)[9] |
| SQ5 | $64,800[4] |
2025 Lexus RX 350:
| Trim | MSRP |
|---|---|
| RX 350 Base (FWD) | $49,950[6] |
| RX 350 Base AWD | $51,550[2] |
| RX 350 Premium AWD | $54,575[6] |
| RX 350 Premium+ AWD | $58,065[6] |
| RX 350 Luxury AWD | $61,520[6] |
Prices include destination fees where noted.
Lexus consistently ranks among the most reliable automotive brands in industry surveys, and the RX benefits from Toyota's robust engineering[5]. This reliability translates to lower unexpected repair costs and stronger resale values over time.
Audi has improved reliability significantly in recent years, though German luxury vehicles historically have higher maintenance costs than Japanese counterparts[4]. The Q5's sophisticated quattro system and turbocharged engine may require more attention as mileage accumulates.
| Factor | Audi Q5 | Lexus RX 350 |
|---|---|---|
| Basic Warranty | 4 yrs/50,000 mi | 4 yrs/50,000 mi |
| Powertrain Warranty | 4 yrs/50,000 mi | 6 yrs/70,000 mi |
| Expected Reliability | Above Average[4] | Excellent[5] |
| Estimated 5-Year Maintenance | Higher | Lower |
Pros:
Cons:
Pros:
Cons:
Choose the Audi Q5 if you:
Choose the Lexus RX 350 if you:
The Q5 delivers exceptional value for its price point and is the right choice for buyers who prioritize efficiency, driving dynamics, and don't need maximum interior space. The RX 350 justifies its higher price with more power, more space, and Lexus's unmatched reliability reputation.
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